Central Melanocortin Receptors Mediate Changes in Food Intake in the Rhesus Macaque*
نویسندگان
چکیده
منابع مشابه
Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.
Injection of the melanocortin-3/4 receptor agonist melanotan-II (MTII) into the nucleus of the solitary tract (NTS) produces rapid and sustained reduction of food intake. Melanocortin-4 receptors (MC4Rs) are expressed by vagal afferent endings in the NTS, but it is not known whether these endings participate in MTII-induced reduction of food intake. In experiments described here, we evaluated t...
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Evidence from animal studies suggests corticotrophin and melanocortin systems have regulatory role in feeding system in avian, but there is no evidence for their interaction. In this survey three experiments designed to investigate the role of corticotrophin receptors on food intake using melanocortin receptors agonist M3 and M4 in neonatal chicken (each experiment includes 4 groups and 11 bird...
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The orexigenic role of central neuropeptide Y (NPY) in nonhuman primates has been questioned. Therefore, we have studied the effect of central NPY on feeding in ad libitum-fed male rhesus macaques. NPY dose-dependently increased food intake, with the maximal effect obtained by 50 microg (960 min food intake +/- SEM, 104 +/- 5 to 188 +/- 11 g; vehicle vs. NPY; n = 6). Blood glucose levels were u...
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The role of endogenous histamine and H1, H2 and H3 central receptors on food intake in broiler chickenswas investigated. For this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (ICV) injection of thioperamide, an H3 receptor antagonist, and R-α-methylhistamine, an H3 receptor agonist and subsequently the effects of brain histaminergic...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2001
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.142.6.8198